Antigen-primed CD8 cells can cause graft failure without major effector pathways.

2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Antigen-primed cytotoxic T cells can cause marrow graft rejection even in the absence of major effector pathways.

"Engraftment failure following allogeneic bone marrow (BM) transplantation is of clinical concern particularly involving T-cell-depleted inoculum and transplantations for aplastic anemia," researchers in the United States explained. "Immune resistance by lymphoid and natural killer (NK) populations with 'barrier' function is well established."

In a study conducted by M. Komatsu and coauthors at the University of Miami, "major histocompatibility complex (MHC)-identical marrow allografts were examined to …